Wallykazam and Sabrina and Ami and Yumi as Scooby-Doo
Penny Proud as Shaggy Rogers
Oscar Proud as Fred Jones
Trudy Proud as Daphne Blake
Kim Possible as Velma Dinkley
Hello Neighbor/Theodore Peterson as Scrappy-Doo
Kareem Abdul-Jabbar Brown as Mary Jane
Alec Baldwin (Team America: World Police) as Melvin Doo
Dr. Carver (Clone) as Emile Mondavarious (Scrappy-Doo)
Dr. Carver as Emile Mondavarious